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Venezuelan equine encephalitis virus (VEEV) is a member of genus Alphavirus in the family Togaviridae|VEEV encodes four nonstructural proteins (nsP1, nsP2, nsP3 and nsP4) and five structural proteins (capsid (C), envelope (E) 3, E2, 6k, and E1)|The Nsp1 gene of VEEV contains a 51-nt conserved sequence element (CSE) that is essential for virus replication|Mutation or deletion of CSE results in loss of infectivity of VEEV, probably due to inefficient recognition of the viral RNA core promoter element by the virus replication complex|Nsp1 functions as a methyltransferase and guanylylation enzyme, two properties needed for the 5' capping of VEEV genomic RNA [PMID: 30781656]
VEEV NSP1
100 µL
100 µL
100 µL
100 µL
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